Diseases And Treatments

Mastocytosis - What It Is, Causes, Symptoms and Treatments

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Mastocytosis - What It Is, Causes, Symptoms and Treatmentsand much more is what you will learn from now, so continue with us and discover everything aboutMastocytosis, a disease that is so dangerous. In additionMastocytosismast cells, which are cells belonging to the group of white blood cells (responsible for infections) and have the function of producing molecules in response to the presence of allergenic substances, leading the patient to a reaction allergic reaction.

THEMastocytosisoccurs after a mutation in the DNA of these mast cells, which begin to multiply wildly and have their altered functions - the most common mutation occurs in a gene called KIT and is present in more than 90% of the cases. This overproduction leads to accumulation of mast cells with problems in the tissues and some organs, but the skin is the most affected of all.

What is Mastocytosis:THEMastocytosisis a set of alterations caused by the presence of abnormal numbers of mast cells. This group of disorders often affect the skin but can be localized to any other part of the body, such as the digestive system, bones and connective tissue.

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Mast cells are responsible for participating in immune and inflammatory reactions, contain histamine and other chemicals which, when released into the surrounding tissue causing various reactions include dilation of the capillaries, swelling and itching development. Often, when a sore or scar to enjoy an itchy sensation in it, it is caused the increased presence of mast cells and release of histamine by itself in the process of healing.

Types of Mastocytosis:THEMastocytosisis a term encompassing several pathologies characterized by the accumulation of mast cells in the skin, with or without compromising other organs and tissues, especially in the bone marrow and in the treatment gastrointestinal. It can be divided into:

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  • Cutaneous mastocytosis (MC):most commonly observed during childhood and usually occurs early. In adults, it usually appears between 30 and 40 years of age.
  • Systemic mastocytosis (MS):is characterized by the accumulation of mast cells in other organs and tissues. It usually appears from the 30 years of age, and can be progressive and even lead to death.

There has been progress in studies of the etiopathogenesis of this disease in recent years, with the disclosure of specific gene mutations. As a result of progress in the knowledge of oncogenesis, growth and differentiation of mast cells, there was a better understanding of the pathologic hyperplasia of this cell, although it has not yet been completely elucidated.

Diagnosis of Mastocytosis:It is evidenced by the high levels of histamine or prostaglandin D2 in the 24-hour urine collected shortly after the crisis and by the increase of the mast cells in the cutaneous lesions (histology).

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Causes of Mastocytosis:The reason for theMastocytosisis unknown. It also affects men and women and is more common in white people. THEMastocytosisusually occurs in children and a small proportion becomes systemic. THEMastocytosisis typical of adolescents and adults. In some situations this mitosis can become malignant and is called mast cell leukemia.

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Symptoms of Mastocytosis:Only oneMastocytosisdoes not cause symptoms. Stains and nodules can cause itching, particularly if scratched or scratched. Itching may worsen with changes in temperature, contact with clothing or other materials, or with the use of some drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs). Consumption of hot drinks, spicy foods or alcohol and exercise can also make itchy. When scratching or scratching the spots, hives may occur and cause the skin to redden.

Redness is common. Peptic ulcers can also develop because there is excessive production of histamine, which stimulates the secretion of excess gastric acid. Ulcers can cause pain in the stomach. Nausea, vomiting and chronic diarrhea may also occur. The abdomen may increase if the liver and spleen malfunction, causing fluid to accumulate inside the abdomen. If the bone marrow is affected, the result may be bone pain.

Disseminated reactions may occur. AtMastocytosissystemic, widespread reactions tend to be severe. These include anaphylactic and anaphylactoid (anaphylactoid versus anaphylactic) reactions that cause fainting and a fall in blood pressure that can be fatal (shock). These resemble anaphylactic reactions, but are not triggered by an allergen. THEMastocytosiscan affect the bone marrow, and up to 30% of adults withMastocytosisdevelop cancer, especially myeloid leukemias. Life expectancy may be reduced for these people.

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Histopathology ofMastocytosis:The normal mast cell has round or oval nuclei and cytoplasm with granules. No nucleolus is observed. A typical UP lesion reveals the presence of mast cells throughout the dermal papilla, extending and entering the reticular dermis. At theMastocytosis, the mast cells have abundant cytoplasm and fill the papillary and reticular dermis, reaching the deep dermis and the subcutaneous cellular tissue. There is no cell atypia. AtMastocytosisdiffuse mastocytic infiltration occurs in the papillary dermis and high reticular. In nodular, plaque or infiltrated lesions, microscopy is usually similar toMastocytosislonely.

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Treatment for Mastocytosis:The general symptoms ofMastocytosiswith mast cell degranulation, so it is very important to insist to the patient and his family on the need to follow the advice of the Patient Information Book withMastocytosis, avoiding all those situations or substances recognized as inducers of this mast cell degranulation.

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