Energy And Resistance

Fattening Pregnenolone? For What It Is, Side Effects, Dosage and Indication

Pregnenola is a steroid hormone responsible for the synthesis of several female sex hormones such as estrogen and progesterone and the male sex hormone testosterone.

Generally, pregnenolone is highly sought after by people who are looking for memory support, energy and stress, since there are studies that indicate that the hormone is able to stimulate and give more energy. However, many doubts arise about the safety of hormone intake as a supplement and the side effects reported by users that involve weight changes and hormonal changes.

Let us clarify if pregnenolone is fattening and discuss the main uses and side effects of this hormone supplement.

Pregnenolone - What is it?

Pregnenolone is a chemical found naturally in our body and can also be synthesized in the laboratory for use in supplements. Pregnenolone is produced from cholesterol through the adrenal glands. It can also be synthesized in organs such as the liver, testicles, ovaries, skin, brain and even the retina of the eye.

What is it for?

The most traditional use of pregnenolone is in the medical field. Pregnenolone is used to prevent fatigue and increase energy, in addition to being used in the treatment of conditions such as Alzheimer's disease, diseases or conditions involving memory loss, skin disorders such as psoriasis and scleroderma, trauma and injuries. This compound is also capable of improving stress symptoms and improving the immune system.

Women often use pregnenolone to treat specific conditions such as fibrocystic breast disease characterized by for irregular breasts, endometriosis, which is a disorder in the lining of the uterus, symptoms of menopause and tension premenstrual syndrome.

Other people also use pregnenolone with the intention of slowing or reversing aging and to relieve symptoms of arthritis and depression. It can also strengthen heart health, prevent allergic reactions, detoxify the body and treat diseases like lupus, multiple sclerosis, prostate problems and seizures.

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How it works

Pregnenolone is a precursor in the body responsible for the synthesis of several steroid hormones essential for the proper functioning of the body. Thus, pregnenolone is converted into important hormones and helps to balance the right hormonal rates in a healthy person. For this reason, pregnenolone has been studied by researchers since the 1940s, mainly to relieve symptoms of stress, fatigue and arthritis.


The use of pregnenolone is indicated for:

  • Slow down the aging process;
  • Arthritis;
  • Depression;
  • Endometriosis.

By being a precursor of several hormones, it can be used to correct some hormonal imbalances that affect health.

The hormone has also attracted a lot of people's attention mainly because of an improvement in mental function. Studies have shown that the hormone affects short- and long-term memory, resulting in increased motivation and better learning ability. In addition, it also boosts the immune system and relieves stress, giving more energy to those who use the product and improving the quality of sleep.

There is also evidence of combating skin aging problems when applied topically over it.

Side effects

Because pregnenolone is used for the synthesis of steroid hormones, the side effects of pregnenolone are similar to those of common steroids, which include:

  • Insomnia;
  • Irritability;
  • Anger and aggression;
  • Anxiety;
  • Acne;
  • Headache;
  • Mood swings;
  • Accelerated metabolism;
  • Facial hair growth;
  • Hair loss;
  • Irregularity in the heart beat.

When you notice that one or more of these symptoms is negatively affecting your life, it is worthwhile to decrease the dose or to stop using the supplement.

Other risks related to the use of pregnenolone

Pregnenolone can stimulate certain cancer cells. Generally, cancer cells have a different division process than healthy cells, including the ability to invade other cells and tissues in the body.

The great proliferation capacity of cancer cells occurs because of their ability to prevent apoptosis, which is the programmed cell death that happens in any normal cell that suffers some kind of alteration unwanted. When using pregnenolone, some types of cancer that are more sensitive to hormonal changes may have such increased proliferation capacity.

There are clinical studies showing that pregnenolone stimulates the growth of prostate cancer cells, as reported in 2000 byJournal of Steroid and Biochemical Molecular Biology.

There are also risks associated with hormone replacement therapies, since pregnenolone itself is a precursor of estrogen and progesterone, and can intensify the side effects of those who already use hormone replacement medicine, such as menopausal women, for example.

Notice for women

Pregnant or breastfeeding women should not use the substance. In addition, pregnenolone is converted into estrogen in the body. Therefore, if you have any medical conditions such as breast cancer, uterine cancer, ovarian cancer or uterine fibroid that can be made worse by exposure to hormone estrogen, it is not recommended to use pregnenolone and the best thing to do is to consult a doctor to discuss the benefits and risks of using the compound.


Pregnenolone may interact with various hormone replacement medications, such as those containing:

  • Estrogen:Because pregnenolone is already converted into estrogen by the body, it is not recommended to use this substance together with a supplement of pregnenolone, as this can cause an excess of estrogen in the body, altering the balance hormonal.
  • Progestin:Progestins are a group of hormones present in the body. Taking these hormones along with pregnenolone can raise the level of hormones in the body, causing a potentiation of the reported side effects.
  • Testosterone:In addition to being transformed into estrogen, pregnenolone also participate in metabolic processes for conversion into testosterone. So, especially if you are a woman, you have to be careful not to over-boost your testosterone levels and cause unwanted side effects.


The appropriate dose of pregnenolone depends on several factors such as age, weight and condition to be treated. The indicated one is to follow the instructions in the label of the substance or medical indication that can vary from 5 to 50 milligrams per day.

Because it is stimulating, its use is not indicated during the night. In addition, the use of pregnenolone for an extended period of time is not indicated due to potentiation of side effects.

Pregnenolone is fattening?

According to scientific and clinical information, it is not possible to say that pregnenolone is fattening. However, because it is a precursor to estrogen, some weight gain may occur. This is because estrogen, very present in many contraceptives, can promote fluid retention and swelling, which gives the sensation of weight gain.

To eliminate this problem, simply have a balanced diet including many vegetables, vegetables and whole foods, and avoid salt and fat that can worsen fluid retention.

  • See more:How to Reduce - Tips to decrease fluid retention.

Thus, we can not say that pregnenolone is fattening. This depends a great deal on metabolism to metabolism and should be carefully considered on a case-by-case basis and on several factors such as the dosage and the source of the supplement. In some cases, for example, it can even make your metabolism get faster, making you lose a little weight.

It should be kept in mind that the function of pregnenolone is not to make you lose or gain weight, but to act on some hormonal changes that can lead to hormonal balance, in addition to cognitive disorders.

Additional references:

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Do you know anyone who has taken and claims that pregnenolone is fattening? Are you afraid to use this supplement because of possible side effects? Comment below!

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