Hemophilia C - What It Is, Causes, Symptoms and Treatmentswhich we can not ignore. In additionhemophilia C, also known as Rosenthal Syndrome, is due to the lack of factor XI, involved in the intrinsic pathway of the coagulation cascade. It's a kind ofhemophiliawhich is usually mild, but may resemblehemophilia Cclassic. It affects both sexes. It is frequently found among Jewish families descended from Ashkenazi Jewish lineages.
THEHemophilia Cis a hereditary bloody disorder in which a person lacks or has low levels of certain proteins called "clotting factors" and the blood does not coagulate properly as a result. This leads to excessive bleeding.
There are 13 types of clotting factors, which work with platelets to help the blood clot. Platelets are small blood cells that form in your bone marrow. According to the World Federation ofHemophilia(WFH), about one in 1, 00 people are born withhemophilia C..
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People withhemophilia Cbleed easily, and the blood takes longer to coagulate. People withhemophilia Cmay experience spontaneous or internal bleeding and often have painful and swollen joints due to bleeding in the joints. This rare but serious condition can have fatal complications. So, check outHemophilia C - What it is, Causes, Symptoms and Treatments.
The Three Forms of Hemophilia:.
Hemophilia A:It's the kind ofhemophilia Cmore common, and is caused by a factor VIII deficiency. According to the National Heart, Lung and Blood Institute (NHLBI), eight of the 10 people withhemophilia ChashemophiliaTHE.
Hemophilia B:It is also called Christmas disease, it is caused by a factor IX deficiency.
Hemophilia C:It is a mild form of the disease that is caused by a factor XI deficiency. People with this type ofhemophilia Crarely do not experience spontaneous bleeding. Bleeding usually occurs after trauma or surgery..
THEhemophilia Cis a hereditary genetic condition. This condition is not curable, but can be treated to minimize symptoms and prevent future health complications. In extremely rare cases, thehemophilia Cmay develop after birth. This is called "hemophilia Cacquired ". This is the case in people whose immune system forms antibodies that attack factors VIII or IX.
Symptoms of Hemophilia C:The extent of your symptoms depends on the severity of your factor deficiency. People with light deficiency may bleed in case of trauma. People with a severe disability may bleed for no reason. This is called "spontaneous bleeding." In children withhemophilia C,these symptoms can occur around 2 years of age.
Spontaneous Bleeding May Cause Next:.
- blood in the urine
- Fecal blood
- Deep contusions
- Large unexplained bruises
- excessive bleeding
- bleeding gums
- Frequent nose bleeds
- Pain in the joints
- Tight joints
- Irritability (in children)
Causes of Hemophilia C:A process in your body that is known as a "coagulation cascade" usually stops bleeding. Blood platelets coagulate, or come together at the site of the wound, to form a clot. Then, the body's coagulation factors work together to create a more permanent plug in the wound. A low level of these clotting factors or the absence of them causes bleeding to continue.
Hemophilia C and genetics:THEhemophilia Cis a hereditary genetic condition, which means that it is transmitted by families. It is caused by a defect in the gene that determines how the body makes the factors VIII, IX or XI. These genes are located on the X chromosome, making thehemophilia Can X-linked recessive disease. Each person inherits two sex chromosomes from their parents. Females have two X chromosomes. Males have one X chromosome and one Y.
Males inherit an X chromosome from their mother and a Y chromosome from their father. Females receive one X chromosome from each parent. Because the genetic defect that causeshemophilia Cis located on the X chromosome, parents can not pass the disease to their children. This also means that if a man obtains the X chromosome with his mother's altered gene, he will havehemophilia C. A female with an X chromosome that has the altered gene has a 50% chance of passing that gene to her children, male or female..
A female that has the altered gene on one of its X chromosomes is typically called a "carrier." This means that she can pass the disease on to her children, but she does not have the disease herself. This is because she has enough coagulation factors from her normal X chromosome to prevent serious bleeding problems.
However, women who are carriers usually have an increased risk of bleeding. Males with an X chromosome that has the altered gene can pass on to their daughters, making them transporters. A female must have this altered gene on both X chromosomes to havehemophilia C.However, this is very rare..
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Hemophilia Treatment C:Your doctor can treat thehemophiliaA with a prescription hormone. This hormone is called desmopressin, which they can give as an injection into your vein. This medicine works by stimulating the factors responsible for the process of blood clotting. Your doctor can treat thehemophiliaB infusing your blood with donor clotting factors. Sometimes the factors can be given in synthetic form. These are called "recombinant coagulation factors"..
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Your doctor can treat thehemophilia Cwith plasma infusion. The infusion works to stop profuse bleeding. The deficient factor responsible forhemophilia Cis only available as a medicine in Europe. You can also go to physical therapy for rehabilitation if your joints are damaged byhemophilia C..
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